Vasodilating actions of eperisone on smooth muscle cells of the guinea-pig basilar artery
نویسندگان
چکیده
منابع مشابه
Eperisone, an antispastic agent, possesses vasodilating actions on the guinea-pig basilar artery.
The effects of eperisone, an antispasmodic, on the electrical and mechanical properties of smooth muscle cells of the guinea-pig basilar artery were investigated. Eperisone (below 50 microM) did not modify the membrane potential, membrane resistance, excitatory junction potential evoked by perivascular nerve stimulation or the K- and 5-hydroxytryptamine-induced depolarizations. However, in conc...
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The hemolysate (10(-5)-10(-2) times dilution; original hemoglobin concentration was 0.83 +/- 0.10 X 10(-3)M) evoked the contraction in a dose dependent manner, and this contraction was composed of low and high sensitive responses as estimated from the Eadie-Hofstee's plot. Indomethacin (10(-7)-10(-5)M) inhibited the latter component in the hemolysate-induced contraction. The membrane potential ...
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pH1 is an important determinant of vascular tone in cerebral blood vessels. We investigated the effects of changes in pH. on isolated smooth muscle cells from the basilar artery of the guinea pig. Single cells contracted rapidly in response to an elevation in pH. (constant C02), and contraction was blocked by nifedipine, suggesting a role for dihydropyridine-sensitive Ca2+ channels. In whole-ce...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1985
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)63932-6